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Publications

Mar 17, 2025

Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles

This study investigated why COVID-19 convalescent plasma (CCP) therapy has shown inconclusive efficacy in treating severe COVID-19.

Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles

Feb 4, 2025

High HIV-1 viremia and low anti-Env antibody responses are associated
with delayed treatment response to fostemsavir in highly
treatment-experienced individuals

This study investigates factors associated with delayed viral suppression in HIV-1 patients receiving fostemsavir (FTR), a first-in-class HIV-1 attachment inhibitor.

High HIV-1 viremia and low anti-Env antibody responses are associated
with delayed treatment response to fostemsavir in highly
treatment-experienced individuals

Dec 18, 2024

Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning

This perspective article discusses recent advancements and challenges in applying machine learning (ML) to analyze adaptive immune receptor repertoires (AIRRs), particularly focusing on B cell receptors (BCRs) and T cell receptors (TCRs).

Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning

Oct 29, 2024

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

This study investigates the transcriptional changes in immune cell genes during the progression of COVID-19, comparing mild and severe cases.

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

May 7, 2024

Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities.

This study examines the antibody responses elicited by the heterologous Ad26/Ad5 adenovirus-vectored vaccines against SARS-CoV-2, comparing them with LNP-mRNA vaccines and natural infection.

Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities.

Jan 12, 2024

Decoding the language of Immunity

This perspective article reviews

Decoding the language of Immunity

Mar 18, 2023

Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence

This study focuses on the immune response in COVID-19 outpatients, specifically examining the role of antibody-dependent natural killer (NK) cell functions during convalescence.

Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence

May 31, 2022

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

This study investigates how IgG responses to the SARS-CoV-2 spike protein, particularly those targeting conserved regions from seasonal coronaviruses (shCoVs), influence COVID-19 disease severity.

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

Jan 5, 2022

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

This study explores the potential of non-neutralizing antibodies targeting HIV-1 envelope regions (V1V2 and V3) to reduce mucosal infection and virus burden in humanized mice.

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

Oct 10, 2021

Therapeutic efficacy of human monoclonal antibodies against mid- and late-stage HCPS caused by Andes orthohantavirus

This study investigates the therapeutic efficacy of human monoclonal antibodies (mAbs) against Andes virus (ANDV), the causative agent of hantavirus cardiopulmonary syndrome (HCPS).

Therapeutic efficacy of human monoclonal antibodies against mid- and late-stage HCPS caused by Andes orthohantavirus

Aug 31, 2021

Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission

This study investigates the role of an endocytic motif on HIV-1 Env (envelope protein) in modulating the co-transfer of Env and Gag (structural protein) during HIV-1 cell-cell transmission through virological synapses (VSs).

Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission

Mar 19, 2021

Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

This study examines the immune responses associated with Choclo Orthohantavirus (CHOV) infection, which causes hantavirus cardiopulmonary syndrome (HCPS) in Panama.

Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

Aug 24, 2020

Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein

This study examines the CD4+ T regulatory (Treg) cell phenotype in survivors of Andes Hantavirus Cardiopulmonary Syndrome (HCPS) to understand how the immune system regulates the infection and disease outcomes.

Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein

Feb 28, 2020

P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion

This study investigates the use of P2X1 receptor antagonists, NF279 and NF449, to block HIV-1 infection, focusing on their ability to inhibit viral fusion.

P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion

Jul 24, 2019

Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV

This review article discusses the role of V1V2-specific antibodies (Abs) in controlling or protecting against HIV, SIV, and SHIV infections, with a focus on the immune response triggered by vaccines.

Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV

Nov 21, 2018

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

This study identifies two recombinant human monoclonal antibodies (mAbs), JL16 and MIB22, that protect against lethal Andes hantavirus (ANDV) infection in a Syrian hamster model of hantavirus cardiopulmonary syndrome (HCPS).

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

Feb 23, 2017

Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG

This study investigates the Fc-gamma receptor (FCGR) activation profiles of IgG antibodies (Abs) from HIV viremic controllers (VCs) and how they contribute to immune responses against HIV.

Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG

Dec 18, 2014

Unique Features of HIV-1 Spread through T Cell Virological Synapses

This review focuses on the unique features of HIV-1 transmission through virological synapses (VS), which are specialized structures formed between infected and uninfected T cells.

Unique Features of HIV-1 Spread through T Cell Virological Synapses

Jun 2, 2014

HIV-1 Vpu Antagonism of Tetherin Inhibits Antibody-Dependent Cellular Cytotoxic Responses by Natural Killer Cells

This study by Alvarez et al. (2014) investigates how the HIV-1 Vpu protein antagonizes the host protein tetherin to avoid immune detection and clearance, specifically inhibiting antibody-dependent cellular cytotoxicity (ADCC).

HIV-1 Vpu Antagonism of Tetherin Inhibits Antibody-Dependent Cellular Cytotoxic Responses by Natural Killer Cells

Aug 1, 2013

Postintegration HIV-1 Infection of Cervical Epithelial Cells Mediates Contact-Dependent Productive Infection of T Cells

This study investigates how post-integration HIV-1 infection in cervical epithelial cells contributes to the contact-dependent productive infection of CD4+ T cells.

Postintegration HIV-1 Infection of Cervical Epithelial Cells Mediates Contact-Dependent Productive Infection of T Cells

Dec 19, 2012

Mechanisms of enhanced HIV spread through T-cell virological synapses

Mechanisms of enhanced HIV spread through T-cell virological synapses

May 5, 2011

WFDC1 expression identifies memory CD4 T lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions

This study investigates the role of the whey acidic protein (ps20), a member of the WFDC1 family, in promoting HIV-1 transmission between CD4+ T cells, specifically through enhancing intercellular adhesion.

WFDC1 expression identifies memory CD4 T lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions

Nov 3, 2008

Expression of CD86 on Human Islet Endothelial Cells Facilitates T Cell Adhesion and Migration

This study explores the role of CD86 expression on human islet endothelial cells (ECs) in facilitating the adhesion and migration of T cells, particularly CD4+ T cells.

Expression of CD86 on Human Islet Endothelial Cells Facilitates T Cell Adhesion and Migration

Jan 1, 2008

WFDC1/ps20 is a novel innate immunomodulatory signature protein of HIV-permissive memory T cells that promotes infection by up-regulating CD54 expression.

This study identifies the WFDC1/ps20 protein as a key factor influencing the permissiveness of CD4+ T cells to HIV-1 infection.

WFDC1/ps20 is a novel innate immunomodulatory signature protein of HIV-permissive memory T cells that promotes infection by up-regulating CD54 expression.

May 15, 2005

CpG-Independent Synergistic Induction of β-Chemokines and a Dendritic Cell Phenotype by Orthophosphorothioate Oligodeoxynucleotides and Granulocyte-Macrophage Colony-Stimulating Factor in Elutriated Human Primary Monocytes

This study investigates how orthophosphorothioate oligodeoxynucleotides (PS-ODN) and granulocyte-macrophage colony-stimulating factor (GM-CSF) work together to enhance immune responses in human primary monocytes.

CpG-Independent Synergistic Induction of β-Chemokines and a Dendritic Cell Phenotype by Orthophosphorothioate Oligodeoxynucleotides and Granulocyte-Macrophage Colony-Stimulating Factor in Elutriated Human Primary Monocytes

Aug 11, 2004

Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4

Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4

Dec 1, 2001

Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages

This study investigates the role of tyrosine phosphorylation in the ligand-independent sequestration of the CXCR4 receptor in human primary monocytes-macrophages.

Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages

Nov 1, 2001

Early response gene expression during differentiation of cultured Leishmania donovani

Early response gene expression during differentiation of cultured Leishmania donovani
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