Publications
Feb 4, 2025
High HIV-1 viremia and low anti-Env antibody responses are associated
with delayed treatment response to fostemsavir in highly
treatment-experienced individuals
This study investigates factors associated with delayed viral suppression in HIV-1 patients receiving fostemsavir (FTR), a first-in-class HIV-1 attachment inhibitor.
Dec 18, 2024
Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning
This perspective article discusses recent advancements and challenges in applying machine learning (ML) to analyze adaptive immune receptor repertoires (AIRRs), particularly focusing on B cell receptors (BCRs) and T cell receptors (TCRs).
Oct 29, 2024
Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression
This study investigates the transcriptional changes in immune cell genes during the progression of COVID-19, comparing mild and severe cases.
May 7, 2024
Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities.
This study examines the antibody responses elicited by the heterologous Ad26/Ad5 adenovirus-vectored vaccines against SARS-CoV-2, comparing them with LNP-mRNA vaccines and natural infection.
May 31, 2022
IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes
This study investigates how IgG responses to the SARS-CoV-2 spike protein, particularly those targeting conserved regions from seasonal coronaviruses (shCoVs), influence COVID-19 disease severity.
Jan 5, 2022
Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
This study explores the potential of non-neutralizing antibodies targeting HIV-1 envelope regions (V1V2 and V3) to reduce mucosal infection and virus burden in humanized mice.
Oct 10, 2021
Therapeutic efficacy of human monoclonal antibodies against mid- and late-stage HCPS caused by Andes orthohantavirus
This study investigates the therapeutic efficacy of human monoclonal antibodies (mAbs) against Andes virus (ANDV), the causative agent of hantavirus cardiopulmonary syndrome (HCPS).
Aug 31, 2021
Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission
This study investigates the role of an endocytic motif on HIV-1 Env (envelope protein) in modulating the co-transfer of Env and Gag (structural protein) during HIV-1 cell-cell transmission through virological synapses (VSs).
Aug 24, 2020
Differential CD4 T Regulatory Cell Phenotype Induced by Andes Hantavirus Glycoprotein
This study examines the CD4+ T regulatory (Treg) cell phenotype in survivors of Andes Hantavirus Cardiopulmonary Syndrome (HCPS) to understand how the immune system regulates the infection and disease outcomes.
Jul 24, 2019
Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV
This review article discusses the role of V1V2-specific antibodies (Abs) in controlling or protecting against HIV, SIV, and SHIV infections, with a focus on the immune response triggered by vaccines.
Nov 21, 2018
Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.
This study identifies two recombinant human monoclonal antibodies (mAbs), JL16 and MIB22, that protect against lethal Andes hantavirus (ANDV) infection in a Syrian hamster model of hantavirus cardiopulmonary syndrome (HCPS).
Jun 2, 2014
HIV-1 Vpu Antagonism of Tetherin Inhibits Antibody-Dependent Cellular Cytotoxic Responses by Natural Killer Cells
This study by Alvarez et al. (2014) investigates how the HIV-1 Vpu protein antagonizes the host protein tetherin to avoid immune detection and clearance, specifically inhibiting antibody-dependent cellular cytotoxicity (ADCC).
May 5, 2011
WFDC1 expression identifies memory CD4 T lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions
This study investigates the role of the whey acidic protein (ps20), a member of the WFDC1 family, in promoting HIV-1 transmission between CD4+ T cells, specifically through enhancing intercellular adhesion.
May 15, 2005
CpG-Independent Synergistic Induction of β-Chemokines and a Dendritic Cell Phenotype by Orthophosphorothioate Oligodeoxynucleotides and Granulocyte-Macrophage Colony-Stimulating Factor in Elutriated Human Primary Monocytes
This study investigates how orthophosphorothioate oligodeoxynucleotides (PS-ODN) and granulocyte-macrophage colony-stimulating factor (GM-CSF) work together to enhance immune responses in human primary monocytes.